Fancast[]
- Emma Watson as Twilight Sparkle [voice]
- Jack McBrayer as Wander [voice]
- Johnny Depp as Grim Reaper [voice]
- Tom Holland as Ansi Molina
- Olivia Cooke as Agent Xero
- Elle Fanning as Star Butterfly
- Dyan O'brien as Marco Diaz
- Huck Milner as Favireton Sparkle [voice]
- Nikki Hahn as Lydia Rose Nomad [voice]
- Gaten Matarazzo as Dipper Pines
- Oona Laurence as Mabel Pines
- Robert De Niro as Grunkle Stan
- Bella Thorne as Wendy Corduroy
- Tobey Maguire as Squint
- Eleanor Worthington-Cox as Sarah Corduroy
- Corey Fogelmanis as Densa Sheriff
- Eddie Redmayne as Jamie
- Raffey Cassidy as Jenna Foster
- Alexander Molony as Hubie Foster
- Kevin James as Soos Ramirez
- J.K. Simmons as Ford Pines
- Ethan Slater as Olly Timbers
- Kira Kosarin as Saraline Timbers
- Max Charles as K.O.
- Jennifer Lawrence as Enid
- Dwayne Johnson as Radicles
- Owen Wilson as Rapido [voice]
- Josh Gad as Razmo [voice]
- Liu Yifei as Ami Onuki
- Malese Jow as Yumi Yoshimura
- Danny De Vito as Kaz Harada
- Bill Hader as Mole [voice]
- Colin Farrell as Grim Gloom
- Helena Bonham Carter as Hildy Gloom
- Adam Sandler as Vlad
- Emma Thompson as Queen Moon
- Alan Tudyk as King Riven
- Kate McKinnon as Carol
- David Tennant as Katz
- Kelsey Grammer as Mr. Gar
- Grant Palmer as Lincoln Loud
- Jennette McCurdy as Lori Loud
- Emilia Jones as Leni Loud
- Rowan Blanchard as Luna Loud
- Molly Jackson as Luan Loud
- Georgie Henley as Lynn Loud
- Anna Cathcart as Lucy Loud
- Ella Anderson as Lola Loud
- Hadley Belle Miller as Lana Loud
- Pixie Davies as Lisa Loud
- Baby as Lily Loud
- Ewan McGregor as Mr. Woop Man
- Ariana Grande as Applejack [voice]
- Dove Cameron as Pinkie Pie [voice]
- Sarah Silverman as Rainbow Dash [voice]
- Cameron Diaz as Rarity [voice]
- Mandy Moore as Fluttershy [voice]
- Ellen DeGeneres as Sylvia [voice]
- Reese Witherspoon as Rita Loud
- Hugh Jackman as Lynn Loud Sr.
- Katie Crown as Frankie Foster
- Jenny Slate as Pony Head [voice]
- Jacob Tremblay as Timmy Turner
- Dan Castenatella as Cosmo
- Julie Kavner as Wanda
- Jaeda Lily Miller as Chloe Carmichael
- Jake Gyllenhaal as Sparky [voice]
- Ben Schwartz as Sonic The Hedgehog [voice]
- Miles Christopher Bakshi as Miles ''Tails'' Prower [voice]
- Seth Rogen as Knuckles The Echidna [voice]
- Selena Gomez as Amy Rose [voice]
- Chris Hemsworth as Shadow The Hedgehog [voice]
- Beyonce Knowles as Rouge The Bat [voice]
- Scarlett Johansson as Anairis Q
- Angela Bettis as Bryan V
- Idris Elba as Jonah Bishop
- Timothy Spall as George The Doorman
- Alfred Molina as Albert Molina
- Warwick Davis as Doc
- Peter Dinklage as Grumpy
- Tony Cox as Happy
- Martin Klebba as Sleepy
- Toby Jones as Bashful
- Danny Woodburn as Sneezy
- Sam Humphrey as Dopey
- Mariel Sheets as Blossom
- Cameron Seely as Bubbles
- Taylor Geare as Buttercup
- Neel Sethi as Mac Foster
- Paul Reubens as Bloo [voice]
- Will Smith as Wilt [voice]
- Zach Galigianakis as Eduardo [voice]
- Frank Welker as Coco [voice]
- Amy Adams as Queen Delighful
- Steve Carrell as Lord Starchbottom
- Ed Skrein as Discord [voice]
- Justin Theroux as Professor Utonium
- Christina Hendricks as Ms. Keane
- Christopher Lloyd as Mayor of Townsville
- Betsy Rue as Miss Bellum
- Sacha Baron Cohen as Mr. Herriman [voice]
- Cloris Leachman as Madame Foster
- Julianne Moore as The Spy from Apartment 8-I
- Joaquin Phoenix as Black Hat [voice]
- Jack Nicholson as Lord Boxman
- Andy Serkis as Masterson
- Mark Povinelli as Ludo [voice]
- Tom Cruise as Toffee [voice]
- Benedict Cumberbatch as Baron Vain
- Daniel Ratcliffe as Rat [voice]
- Tracy Morgan as Flowershirt
- Billy Zane as Lord Hater [voice]
- Margot Robbie as Lord Dominator
- Bill Skarsgard as Bill Cipher [voice]
- Jack Black as Nicolai
- Reid Scott as Mitch
- Greg Proops as Denzel Crocker
- Booboo Stewart as Danny Fenton
- Chloe Grace Moretz as Jenny Wakeman
- Patrick Stewart as Mojo Jojo [voice]
- BD Wong as Samurai Jack
- Gong Li as Ashi
- John Goodman as Scotsman
- Alan Cumming as Aku [voice]
- Caleel Harris as Clyde McBride
- Paul Giamatti as Pop-Pop
- Harrison Ford as Mr. Grouse
- Oakes Fegley as Jamie Jr./Young Grim Gloom
- Kiernan Shipka as Charlie
- Millie Bobby Brown as Vaggie
- Kevin Quinn as Alastor
- Max Gecowets as Angel Dust [voice]
- Jason Lee as Master Frown [voice]
- James Scully as Sir Pentious [voice]
- Dustin Hoffman as King Nixel
- Javier Bardem as The Martian King [voice]
- Cate Blanchett and Girl Baby as Adult/Infant Meteora Butterfly
- Isaac Hempstead Wright as Leif Bornewell III
- Finn Wolfhard as Wendell Wasserman
- Nico Parker as Julia Wiles
- Devon Bostick as Dennis O'Bannon
- Storm Reid as Goodness
- Lilla Crawford as Katherine-Alice
- Mena Massoud as Andrei
- Viola Davis as Clara Rhone
- Tom Cruise as Prisma [voice and play]
- Ansel Elgort as Tom Lucitor
- Sabrina Carpenter as Jackie Lynn Thomas
- Bella Samman as Janna
- Jonathan Sadowski as Rafael Diaz
- Maria Canals Barrera as Angie Diaz
- Ryan Reynolds as Spike [voice]
- Naomi Watts as Princess Celestia [voice]
- Rooney Mara as Princess Luna [voice]
- Charlize Theron as Princess Cadence [voice]
- Edward Norton as Shining Armor [voice]
- Daisy Duczmal as Flurry Heart [voice]
- Liev Schreiber as Storm King [voice]
- Emily Blunt as Tempest Shadow [voice]
- Michael Pena as Grubber [voice]
- Thomas Barbusca as Darrell
- Robbie Amell as Raymond [voice]
- Meagan Good as Shannon
- Thomas Brodie-Sangster as Herby
- Mackenzie Foy as Kirbie
- Nolan Gould as Bert
- Sarah Hyland as Dendy
- Jace Norman and Riele Down as MaXi (Mara and Xilo)
- Mitchell Hope as Joey Felt
- John Travolta as Atomic Puppet [voice]
- Elizabeth Lail as Pauline Bell
- Freddie Highmore as Ratchet [voice]
- Bill Murray as Clank [voice]
- Naomi Scott as The Arcsine
- Brenton Thwaites as Leo San Juan
- Ella Purnell as Marcella
- Amanda Seyfried as Teodora Villavicencio
- Ben Kingsley as Don Andres
- Donald Glover as Alebrije [voice]
- Diego Luna as El Chacas
- Bobby Moynihan as Cuts [voice]
- Charlie Wright as Boyo
- Dakota Fanning as Pacifica Northwest
- Jack Gleeson as Gideon Gleeful
- Christopher Mintez-Plasse as Robbie Valentino
- Ralph Fiennes as Professor Venomous
- Presley Smith as Fink
- Jeffrey Tambor as Glossaryck
- Kevin McNally as Buff Frog [voice]
- Jake T. Austin as Billy
- Zoe Margaret Colletti as Mandy [America]
- David Warner as Nergal [voice]
- Wayne Knight as Jack O'Lantern [voice]
- Fred Willard as The Boogeyman
- Madison Davensport as Young Twilight Sparkle [voice]
- Grant Palmer as Young Wander [voice]
- Collin Dean as Young Grim Reaper [voice]
- Tex Hammond as Young Rapido [voice]
- Anthony Gonzalez as Young Razmo [voice]
- Peigi Barker as Young Sylvia [voice]
- Ruby Barnhill as Young Hildy Gloom
- Jaeden Martell as Young Vlad
- Russell Brand as Ballister Blackheart [Ghost]
- Richard Kind as Harvey Timbers
- Annie Potts as Olympia Timbers
- Rob Riggle as Viktor
- Rico Rodriguez as Steven Universe
- Anne Hathaway as Pearl
- Kat Dennings as Amethyst
- Estelle as Garnet
- John Leguizamo as Zig [voice]
- Brad Garrett as Sharko [voice]
- Trayor Howard as Marina
- Dee Bradley Barker as Bernie [voice]
- Christian Bale as Dracula
- Anna Kendrick as Mavis
- Andy Samberg as Jonathan Loughran
- Danny McBride as Frankenstein
- Fran Drescher as Eunice
- Denis Leary as Wayne The Werewolf [voice]
- Molly Shannon as Wanda The Werewolf [voice]
- Keegan-Michael Key as Murray The Mummy [voice]
- David Spade as Griffin The Invisible Man [voice]
- Asher Blinkoff as Dennis
- Sadie Sandler as Winnie The Werewolf [voice]
- Kathryn Hahn as Ericka Van Helsing
- Mel Brooks as Vlad Dracula
- Eva Green as Eclipsa Butterfly
- Dianna Agron as Kelly
- Zosia Mamet as Hekapoo
- Anthony Anderson as Rhombulus [voice]
- John Cena as Talon Raventalon [voice]
- Craig Ferguson as Omnitraxus Prime [voice]
- Rowan Atkinson as Sean [voice]
- Zendaya as Anne Boonchuy
- Wyatt Hall as Sprig [voice]
- Debby Ryan, Peyton List and Keke Palmer as Apple Bloom, Sweetie Belle and Scootaloo [voices]
- Charlie Day as Commander Peepers [voice] [cameo]
- James Corden as Meddlen Meadows [voice]
- Taye Diggs as Capper [voice]
- Zoe Saldana as Captain Celaeno [voice]
- Ella Wahlestedt as Princess Skystar [voice]
- Uzo Aduba as Queen Novo [voice]
- Paul F. Tompkins as First Mate Mullet [voice]
- Max Martini as Boyle [voice]
- Rosie Ede as Lix Little [voice]
- Sia as Songbird Serenade [voice]
- Tom Kenny as John Keats [voice]
- Norm MacDonald as Norm The Genie
- Joseph Gatt as Jack Rabbit [voice]
- Michael Sheen, David Denman, Winona Ryder, Annasophia Robb as The Vampires
- Jody Halse, Michael Welch, Bella Heathcote, Kris Kristofferson, Casper Van Dien and Jason Schwartzman as Deadly Six [voices]
- Carlos Pena as Bobby Santiago
- Izabella Alvarez as Ronnie-Anne Santiago
- Sean Connery as Star Swirl The Bearded [voice]
- James Marsden as Flint Lockwood
- Mackenzie Mauzy as Sam Sparks
- Chris Renaud as Steve [voice]
- Leigh-Allyn Baker as Snazzy Shazam
- Chiwetel Ejiofor as The Captain
- Ken Jeong as Benny
- Pam Ferris as Svetlana
- Jeff Daniels as Flip