My Little Pony/Despicable Me 3 (2017)

Cast

 * Discord as Gru (both are bad but good guys)
 * Fluttershy as Lucy Wilde
 * Twilight Sparkle as Margo (both are brainy)
 * Rarity as Edith
 * Spike as Agnes (both are youngest as child)
 * Unicorn Toy as Rainbow Monkey (from Kids Next Door)
 * Eduardo as Flim and Flam
 * Gilda as Dr. Nefario